Hi Norbury, Ex-Nuendo 4 user here. I saw similar issues with my Presonus Firestudio and the fix was to check "Ignore ASIO reset messages (needed for some buggy drivers)" option under Preferences/Audio/Device. Also, I have a client that is using Cubase 5 and the MR816 on Win XP and has experienced many BSOD all of which either pointed to his iLok or his MR816. If you would like, go to C:\Windows\Minidumps. Zip up all of the files and email them to me at . I'll look at them for you and let you know what I find.